Generic Name: lidocaine injection (LYE doe kane)
Brand names: Anestacaine, UAD Caine, Xylocaine HCl, Xylocaine-MPF, ...show all 13 brand names.
What is lidocaine injection?
Lidocaine is a local anesthetic (numbing medication). It works by blocking nerve signals in your body.
Lidocaine injection is used to numb an area of your body to help reduce pain or discomfort caused by invasive medical procedures such as surgery, needle punctures, or insertion of a catheter or breathing tube.
Lidocaine injection is also given in an epidural (spinal block) to reduce the discomfort of contractions during labor.
Lidocaine injection is sometimes used to treat irregular heart rhythms that may signal a possible heart attack.
Lidocaine injection may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about lidocaine injection?
You should not receive this medication if you are allergic to lidocaine or any other type of numbing medicine.
Before you receive lidocaine injection, tell your doctor if you have liver or kidney disease, heart disease, coronary artery disease, circulation problems, or a history of malignant hyperthermia.
To treat irregular heart rhythms, your doctor may prescribe a LidoPen auto-injector. This is a prefilled automatic injection device to be used in an emergency. Keep the device with you at all times.
Your doctor will describe the signs and symptoms to watch for when deciding when it's time to use lidocaine injection at home. Never use the LidoPen auto-injector without first calling your doctor.
With the LidoPen auto-injector you will also receive a CardioBeeper to transmit your heart rate and rhythm to your doctor over a telephone. Read all provided instructions and practice using the CardioBeeper.
Lidocaine can cause side effects that may impair your thinking or reactions. Unless absolutely necessary, do not drive after using this medication
What should I discuss with my healthcare provider before receiving lidocaine injection?
You should not receive this medication if you are allergic to lidocaine or any other type of numbing medicine.
If you have any of these other conditions, you may need a dose adjustment or special tests to safely use lidocaine injection:
- liver disease;
- kidney disease;
heart disease;
coronary artery disease, circulation problems; or
a history of malignant hyperthermia.
FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether lidocaine injection passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How is lidocaine injection given?
Lidocaine is given as an injection through a needle placed into a vein or directly into the body area to be numbed. Your doctor, nurse, or other healthcare provider will give you this injection.
Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are receiving lidocaine injection in a hospital setting.
To treat irregular heart rhythms, you may be shown how to use your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of needles and other items used in giving the medicine.
The LidoPen auto-injector is a prefilled automatic injection device to be used in an emergency. Keep the device with you at all times. Your doctor will describe the signs and symptoms to watch for when deciding when it's time to use the injection.
Never use the LidoPen auto-injector without first calling your doctor.
Do not use the auto-injector in or near a vein or into your buttocks. Inject the medication only in your upper thigh or upper arm.
With the LidoPen auto-injector you will also receive a CardioBeeper. This device is used to transmit your heart rate and rhythm to your doctor over a telephone. Read all provided instructions and practice using the CardioBeeper so you will be able to quickly use it in an emergency.
Store the LidoPen auto-injector at room temperature away from moisture and extreme hot or cold.
What happens if I miss a dose?
Since lidocaine injection is used only when needed, you are not likely to be on a dosing schedule.
Never use the LidoPen auto-injector without first calling your doctor.
What happens if I overdose?
Seek emergency medical attention if you think you have received too much of this medicine.
Overdose symptoms may include drowsiness, confusion, nervousness, ringing in your ears, blurred vision, feeling hot or cold, numbness, muscle twitches, uneven heartbeats, seizure (convulsions), slowed breathing, or respiratory failure (breathing stops).
What should I avoid while receiving lidocaine injection?
Lidocaine can cause side effects that may impair your thinking or reactions. Unless absolutely necessary, do not drive after using this medication
Avoid eating or chewing within 1 hour after lidocaine injection is used to numb your mouth or throat. You may have trouble swallowing which could lead to choking. You may also accidentally bite the inside of your mouth if you are still numb an hour after treatment with lidocaine injection.
Lidocaine injection side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your caregivers at once if you have any of these serious side effects:
feeling anxious, shaky, dizzy, restless, or depressed;
drowsiness, vomiting, ringing in your ears, blurred vision;
confusion, twitching, seizure (convulsions);
fast heart rate, rapid breathing, feeling hot or cold;
weak or shallow breathing, slow heart rate, weak pulse; or
feeling like you might pass out.
Less serious side effects include:
mild bruising, redness, itching, or swelling where the medication was injected;
mild dizziness;
nausea;
numbness in places where the medicine is accidentally applied.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Lidocaine injection Dosing Information
Usual Adult Dose for Arrhythmias:
Initial dose: 1 to 1.5 mg/kg/dose intravenously (IV) given over 2 to 3 minutes.
May repeat with 0.5 to 0.75 mg/kg/dose IV given over 2 to 3 minutes in 5 to 10 minutes until a total of 3 mg/kg.
Continuous IV infusion: 1 to 4 mg/min.
Prehospital post-myocardial infarction (MI) antiarrhythmic prophylaxis: 300 mg intramusculary once.
May be administered endotracheally (loading dose only) if IV access unavailable at a dose of 2 to 2.5 times the IV dose. Dilute in 10 mL NS or distilled water.
Usual Adult Dose for Ventricular Fibrillation:
Ventricular fibrillation (VF) or pulseless ventricular tachycardia (VT) (after defibrillation and epinephrine or vasopressin):
Initial dose: 1 to 1.5 mg/kg/dose intravenously (IV).
May repeat 0.5 to 0.75 mg/kg/dose at 5 to 10 minute intervals; maximum total dose: 3 mg/kg.
Follow with continuous IV infusion after return of perfusion; continuous IV infusion: 1 to 4 mg/minute.
Note: Use only bolus doses for cardiac arrest caused by VF or pulseless VT.
May be administered endotracheally (loading dose only) if IV access unavailable at a dose of 2 to 2.5 times the IV dose. Dilute in 10 mL NS or distilled water.
Prevention of ventricular fibrillation: IV bolus: 0.5 mg/kg/dose; repeat every 5 to 10 minutes to a total dose of 2 mg/kg.
Usual Adult Dose for Ventricular Tachycardia:
Ventricular fibrillation (VF) or pulseless ventricular tachycardia (VT) (after defibrillation and epinephrine or vasopressin):
Initial dose: 1 to 1.5 mg/kg/dose intravenously (IV).
May repeat 0.5 to 0.75 mg/kg/dose at 5 to 10 minute intervals; maximum total dose: 3 mg/kg.
Follow with continuous IV infusion after return of perfusion; continuous IV infusion: 1 to 4 mg/minute.
Note: Use only bolus doses for cardiac arrest caused by VF or pulseless VT.
May be administered endotracheally (loading dose only) if IV access unavailable at a dose of 2 to 2.5 times the IV dose. Dilute in 10 mL NS or distilled water.
Prevention of ventricular fibrillation: IV bolus: 0.5 mg/kg/dose; repeat every 5 to 10 minutes to a total dose of 2 mg/kg.
Usual Adult Dose for Anesthesia:
Anesthesia, local injectable: Dose varies with procedure, degree of anesthesia needed, vascularity of tissue, duration of anesthesia required, and physical condition of patient; maximum dose: 4.5 mg/kg/dose; do not repeat within 2 hours.
Usual Pediatric Dose for Ventricular Fibrillation:
For use in pulseless VT or VF; give after defibrillation and epinephrine:
Loading dose: 1 mg/kg (maximum: 100 mg/dose) intravenously; may administer second bolus of 0.5 to 1 mg/kg if delay between bolus and start of infusion is more than 15 minutes.
Follow with continuous intravenous infusion: 20 to 50 mcg/kg/minute.
Continuous infusion: 20 to 50 mcg/kg/minute: Use 20 mcg/kg/minute in patients with shock, hepatic disease, cardiac arrest, or mild CHF. Moderate-to-severe CHF may require one-half the loading dose and lower infusion rates to avoid toxicity.
Endotracheal tube (if IV access unavailable - loading dose only): 2 to 3 mg/kg; flush with 5 mL of NS and follow with 5 assisted manual ventilations.
Usual Pediatric Dose for Ventricular Tachycardia:
For use in pulseless VT or VF; give after defibrillation and epinephrine:
Loading dose: 1 mg/kg (maximum: 100 mg/dose) intravenously; may administer second bolus of 0.5 to 1 mg/kg if delay between bolus and start of infusion is more than 15 minutes.
Follow with continuous intravenous infusion: 20 to 50 mcg/kg/minute.
Continuous infusion: 20 to 50 mcg/kg/minute: Use 20 mcg/kg/minute in patients with shock, hepatic disease, cardiac arrest, or mild CHF. Moderate-to-severe CHF may require one-half the loading dose and lower infusion rates to avoid toxicity.
Endotracheal tube (if IV access unavailable - loading dose only): 2 to 3 mg/kg; flush with 5 mL of NS and follow with 5 assisted manual ventilations.
Usual Pediatric Dose for Anesthesia:
Anesthesia, local injectable: Dose varies with procedure, degree of anesthesia needed, vascularity of tissue, duration of anesthesia required, and physical condition of patient; maximum dose: 4.5 mg/kg/dose; do not repeat within 2 hours.
What other drugs will affect lidocaine injection?
There may be other drugs that can interact with lidocaine injection. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
More lidocaine injection resources
- Lidocaine injection Dosage
- Lidocaine injection Use in Pregnancy & Breastfeeding
- Lidocaine injection Drug Interactions
- Lidocaine injection Support Group
- 1 Review for Lidocaine - Add your own review/rating
Compare lidocaine injection with other medications
- Anesthesia
- Arrhythmia
- Burning Mouth Syndrome
- Ventricular Fibrillation
- Ventricular Tachycardia
Where can I get more information?
- Your doctor or pharmacist can provide more information about lidocaine injection.
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